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This instability may result from inadequate demethylation of conserved non-coding sequence regions in the Foxp3 locus, known as the Treg-specific demethylation region (TSDR), which is fully demethylated in thymus-derived Tregs (tTregs) but often methylated in iTregs ( in vitro systems, and their physiological relevance, particularly in human disease, requires further validation

Brunet, L

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